Obesity is a risk factor for breast cancer in older women.
Book Title: Obesity and Breast Cancer
Author:Kristy A. Brown,Evan R. Simpson
Published on 2013-11-21 by Springer Science & Business Media
ISBN: 9781489980021 / 1489980024
Total Page: 56
Book Category:Medical
Book is About: Breast Cancer
Get Obesity and Breast Cancer eBook
Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research.\u200b
From the most popular Breast Cancer Books, Obesity and Breast Cancer is the one of great book to have. You can get ebook from:
Kristy A. Brown,Evan R. Simpson
There are so many ebooks about Obesity and Breast Cancer that are available to have. Thinking of having Obesity and Breast Cancer ebook? You are in the right place. Get the ebook Obesity and Breast Cancer by:Kristy A. Brown,Evan R. Simpson.
- Book was ranked at 23 by Google Books for Obesity and Breast Cancer
- Obesity and Breast Cancer published by Springer Science & Business Media since 2013-11-21 with ISBNs. The book ISBN 13 Code is 9781489980021 and ISBN 10 Code is 1489980024
- Reading Mode in Text Status is true and Reading Mode in Image Status is true
- The book has "56 Pages" is Printed at BOOK underMedicalCategory
- Rated by Raters and have average rate at ""
- eBook Maturity (Adult Book) status is NOT_MATURE
- eBook written in en
- Book Preview Address: http://books.google.com/books?id=KU-6BAAAQBAJ&printsec=frontcover&dq=Breast+Cancer&hl=&cd=102&source=gbs_api
Book Preview
- Server 2: SECURE LINK