Shorter time from t-MDS diagnosis to death was observed in younger patients. Shorter time from t-MDS to death occurred with multiple cytogenetic abnormalities. Only patients treated with stem cell transplantation obtained cure.
Book Title: Therapy-related Myelodysplastic Syndrome Following Primary Breast Cancer
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Published on 2016 by
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Book is About: Breast Cancer Treatment
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Highlights: t-MDS risk post breast cancer was 30 times that expected among younger patients. Shorter time from t-MDS diagnosis to death was observed in younger patients. Shorter time from t-MDS to death occurred with multiple cytogenetic abnormalities. Only patients treated with stem cell transplantation obtained cure. Annual complete blood counts may be warranted for younger breast cancer patients. Abstract: Background: Therapy-related myelodysplastic syndrome (t-MDS) is a serious clinical disease occurring after breast cancer treatment. Methods: A cohort of 11, 684 invasive breast cancer (BC) patients from 1990–2014 were followed for incidence of t-MDS through institutional and the Surveillance, Epidemiology and End Results (SEER) Program registries. t-MDS cases were identified using ICD-O SEER registry codes, pathology and chart reports. Treatment, cytogenetics, and time from BC diagnosis to t-MDS and t-MDS diagnosis to last follow up or death were obtained. Incidence rate ratios were calculated using SEER national incidence rates for comparison. Results: 27 cases of t-MDS post BC treatment were confirmed. 96% of cases were breast cancer stage I–II at diagnosis. All patients had received radiation treatment and 59% received adjuvant chemotherapy. Two patients were alive with no evidence of disease after treatment with stem cell transplantation (age 33 and 46). t-MDS incidence was 30 times the expected population rate among patients
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