DNA Vaccines Suppress Angiogenesis and Protect Against Growth of \u003cb\u003eBreast\u003c/b\u003e \u003cbr\u003e\n\u003cb\u003eCancer\u003c/b\u003e Metastases N. Mizutani, Y. Luo, M. Mizutani, R.A. Reisfeld and R. Xiang \u003cbr\u003e\nThe Scripps Research Institute, 10550 N. Torrey Pines Rd., IMM13, La Jolla, CA.
Book Title: Immunology of Breast Cancer
Author:Wei-Zen Wei,Diana M. Lopez
Published on 2004 by IOS Press
ISBN: 9781586034948 / 1586034944
Total Page: 153
Book Category:Medical
Book is About: Breast Cancer
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In this issue, exciting new directions are outlined by fourteen groups of investigators working on critical areas in Breast Cancer Immunology. In the clinic, patients are responding to Her-2 peptides or GM-CSF transfected tumor cell vaccines. Futhermore, tumors under vaccine induced immune attack can prime the host to additional antigens. Selected chemotherapeutic agents are used to further vaccine efficacy. These promising results highlight the value of breast cancer immunotherapy. Although the clinical progress is exciting, significant challenges remain. Many tumor-associated antigens are self-antigens and vigorous measures will be required to induce consistent and sustained anti-tumor immunity. There is a pressing need for new immunotherapy targets. In this issue, the better-characterized glycoprotein antigens and novel molecules in angiogenesis are examined as new targets of breast cancer vaccines or immunotherapy. Continued effort in new antigen identification will be critical to cancer control. Finally, a reality check is warranted. Most breast cancer cells are still elusive to immune intervention.The mechanisms of such evasion are under intense investigation and much progress has been made. Alteration in antigen processing machinery is a major route of tumor evasion.
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Wei-Zen Wei,Diana M. Lopez
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